Dr. David Goodlett
Prof. David R. Goodlett has spent his career using mass spectrometry to solve biomedical problems via novel technology and software developments. His Ph.D. training with Prof. Richard B. van Breemen on protein adducts concluded in 1991 and his postdoctoral work with Dr. Richard D. Smith on Native MS and ESI fundamentals in 1993. He has been active in a variety of fields including medicine, oceanography, pharmacy, microbiology, proteomics (including clinical applications), lipidomics, and protein & glycolipid structure-function relationships publishing over 280 papers generating an H-index of 80. His current research interests lie in developing a better understanding of the lipid A structure-activity relationship (SAR) with a goal to elucidate the molecular basis by which lipid A can act as agonist or antagonist on binding to the MD2/TLR4 receptor complex. Having a better understanding of the lipid A SAR will allow more rational design of novel lipid A mimetics that can act as a better vaccine adjuvant than currently used monophosphorylated lipid A and a better anti-septic therapeutic than previously developed, but failed, drug Eritoran. He is currently a Professor at the University of Victoria where he holds the Don and Eleanor Rix BC Leadership Chair in Biomedical & Environmental Proteomics and is Director of their Proteomics Centre. Prior to that he was Professor at the Universities of Washington (2004-2012) and Maryland-Baltimore (2013-2020) as well as first Director of Proteomics at the Institute for Systems Biology (2000-2003). From 2012-2016 he was a Finland Distinguished Professor studying pediatric type 1 diabetes during which time they prepared the following video interview noting work – life balance https://www.youtube.com/watch?v=jfOOMNJivvY. For the last dozen years he has been an Editor at Rapid Communications in Mass Spectrometry for Wiley-Blackwell publishing who have recently produced a Meet the Editors series of interviews found here https://onlinelibrary.wiley.com/doi/abs/10.1002/rcm.8187 where he answers a series of questions related to how he came into science. He has founded two companies based on his patents: Deurion of Seattle, WA (http://deurion.com) who are developing mass spectrometry ion sources and Pataigin of Baltimore, MD (https://pataigin.com) who are focused on microbial diagnostics. Since 2007 he has been a co-organizer of the Mass Spectrometry in Biotechnology and Medicine summer school (www.msbm.org) held annually in Dubrovnik, Croatia. Recently, he was appointed Visiting Professor at the International Centre for Cancer Vaccine Science (ICCVS) at the University of Gdansk where he is helping his long-time colleague Prof Ted Hupp of Edinburgh University with efforts in neoantigen sequencing. His biological focus on understanding the lipid SAR is derived from a decades long collaboration with Prof Bob Ernst of University of Maryland-Baltimore. He is active on twitter as https://twitter.com/goodlettlab1.
Dr. David Schibli
After graduating from the University of Victoria with a Bachelor of Science from the Department of Biochemistry and Microbiology, David went on to obtain his PhD from the University of Calgary in Protein Biochemistry and undertook a post-doctoral fellowship at the European Molecular Biology Laboratory in Grenoble, France. Following this, he was a Project Manager at the University of Western Ontario, where established a new high-throughput proteomics facility. David then went on to obtain his MBA from the Richard Ivey School of Business at the University of Western Ontario, with a specialty in Health Sciences. Since then, David worked at the Ontario Genomics Institute, where he managed the progress and financial performance of large-scale research projects. Following his time at OGI, David was the General Manager of BIG Funding Inc. (BFI), a consulting firm that supports companies in accessing government funding programs. David most recently joined the Uvic-Genome BC Proteomics Centre (PC) as the Associate Director of the Centre in 2015, where he is responsible for the Centre’s operations, administration and finance.
Dr. Jun Han
Lead Scientist - Metabolomics
Dr. Han received his M.S. degree and PhD from China Pharmaceutical University and has 8 years of experience in GLP-compliant analytical method development and validation for regulatory pharmaceutical analysis. Since 2001, Dr. Han received his postdoctoral training at University of North Carolina – Chapel Hill and Medical University of South Carolina, and has acquired extensive research skills and expertise in proteomics and metabolomics. Dr. Han joined the UVic-Genone BC Proteomics Centre in February 2007 and is now a senior scientist and the group leader of metabolomics at the centre. Dr. Han is also an adjunct assistant professor at the Division of Medical Sciences, University of Victoria. He stays current with new developments in the field of mass spectrometry-based metabolomics and plays a key role in technical support and method development of untargeted and targeted metabolomics using diversified LC-MS and MADLI-MS techniques at the Victoria node of The Metabolomics Innovation Centre (TMIC). Since 2009, Dr. Han’s research focus has been on technological development of new UPLC-MRM/MS and UPLC-high-resolution MS methods for high-throughput and full-profile analysis of endogenous metabolites in different metabolic pathways. Dr. Han has published nearly 90 peer-reviewed research and review papers thus far.
Dr. Helena Petrosova
Senior Scientist - MS Imaging
Helena received her MSc and PhD degrees from the Masaryk University, Czech Republic. Her research training comprised fellowships at the Pasteur Institute in Paris, France, and the University of Toronto. Helena’s training is in molecular biology of bacterial pathogens, with a specific focus on spirochetes. Over the course of her studies, she used comparative genomics and genetic manipulation techniques to explore antibiotic resistance and mechanisms of pathogenicity in these bacteria. Helena joined UVic Genome BC Proteomics centre in 2017 to aid development of Multiple Reaction Monitoring (MRM) assays for protein quantification in mouse tissues.
Presently, Helena utilizes Matrix-Assisted Laser Desorption/Ionization (MALDI), MALDI Mass Spectrometry Imaging (MALDI-MSI) and Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) to study bacterial lipids. Lipids form the interface between the bacterial cell and its environment and have various biological activities that are structure dependent. For example, certain structural modifications to lipids confer antibiotic resistance or allow bacteria to escape recognition by the host immune system. Understanding how these structural changes allow bacteria to adapt to the host environment is essential for targeted treatment and prevention of bacterial infections.
Dr. Azad Eshghi
Senior Scientist - Single Cell Proteomics
Azad pursued graduate studies focusing on quantitative proteomics to elucidate bacterial pathogenesis. He was awarded a PhD from the University of Victoria in 2012 and subsequently obtained a postdoctoral research position at the Pasteur Institute, Paris, France from 2012 to 2015. His research at the Pasteur institute focused on utilizing mass spectrometry to characterize extracellular bacterial proteins and bacterial lipid A. From 2015 to 2017 Azad furthered his research experience at the University of Toronto developing a microfluidics assay for screening small molecule inhibitors of bacterial attachment. In 2017 Azad joined the quantitative proteomics team at the Proteomics Centre and has contributed to MRM assay development in mouse tissues and spearheaded MRM assay development in dried blood spots.
Azad’s current research has combined targeted PRM assays with specialized sample preparation strategies, known to the research community as the “one-pot sample preparation method”, to perform quantitative proteomics at the single cell level. The developed methodology has been effective for measuring cellular heterogeneity in red blood cells, which has potential application in diagnosis of diabetic nephropathy and/or detection of blood doping in high performance sports. The workflow has also shown compatibility of with untargeted proteomics for trace sample analysis including near single cell and low-input (protein) quantitative proteomics. Applications include, but are not limited to discovery research where material is available in trace amounts.
Dr. Yassene Mohammed
Lead Scientist - Bioinformatics
Yassene is heading the bioinformatics activities at the Proteomics Centre, focussing on targeted proteomics bioinformatics, clinical applications of proteomics and statistical approaches for MRM and PRM analyses. Yassene is also an assistant professor in bioinformatics at the Center for Proteomics and Metabolomics, Leiden University Medical Center, The Netherlands. In Leiden his research focus on bottom-up and targeted proteomics, -omics data integration, scientific workflows, and eScience. Yassene received his PhD in Medical Informatics from the University of Göttingen, Germany. In the past he has also worked on distributed computing applications, data protection and security in distributed environments, as well as multiphysics simulation and modelling. For more information about our work please check the bioinformatics web site: http://bioinformatics.proteincentre.com.
Grumpy, temperamental, devastatingly handsome. These are just a few of the ways coworkers describe this invaluable member of our team. Derek is truly a joy to be around and makes it a pleasure to come to work every single day.